AUGUST 2024LIFE SCIENCES REVIEW9Unraveling the Complexity of the TranscriptomeRNA sequencing is a powerful tool for making significant discoveries in transcriptomics, from identifying novel biomarkers or molecules that signal a condition of disease to studying differential gene expression. While DNA stores genetic information, RNA transcribes the genetic information in making the proteins that structure, operate and regulate the body. But this helpful tool also comes with a built-in problem. While the crucial messenger RNA (mRNA) exists only briefly because protein is synthesized, ribosomal RNA (rRNA) is never translated into protein, becoming the predominant form of RNA in most cells. Its presence can waste valuable sequencing resources and compromise the detection of the much less abundant mRNA transcripts. To counter this problem, QIAGEN has developed an innovative rRNA removal technology that removes more than 95% of rRNA in 14 minutes to an hour, depending on the organism. This increases RNA sequencing sensitivity and saves resources and costs. Researchers often struggle with limited RNA amounts for sequencing. To help address this challenge, QIAGEN's low-input RNA sequencing technology enables RNA sequencing insights from just 500 pg RNA.Seamless Data Analysis to Make Sense of RNA Sequencing ResultsRNA-seq data analysis is a recurring problem for many researchers. Many data analysis platforms are cumbersome and require researchers to build significant bioinformatics expertise. QIAGEN's rRNA removal and RNA library preparation solutions include access to cloud-based, integrated data analysis. Researchers can seamlessly go from generating RNA-seq data to gaining gene expression insights.From Sample to Insight: Leveraging the True Potential of NGSTo date, up to four million samples have been processed by QIAGEN's growing range of NGS panels. While generating DNA and RNA sequencing data takes substantial effort, deciphering the secrets in the sequence is even more challenging. Researchers have to make sense of the sequencing data to uncover biological insights. Intuitive, integrated data analysis pipelines can help bridge the gap between NGS sequencing, the data it produces, and the actionable insights scientists want. QIAGEN's bioinformatics portfolio stands shoulder-to-shoulder with its sample processing technology and intelligent panel design to leverage the full potential of NGS. QIAGEN is meeting the need for ever faster and more efficient solutions that maximize sequencing capacity through its portfolio strength on front-end sample processing and downstream bioinformatics and extensive application strength across all existing NGS platforms
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